https://doi.org/10.1053/j.semnuclmed.2017.09.007 (2018). Score 4: Uptake moderately increased compared to the liver at any site, Score 5: Uptake markedly increased compared to the liver at any site, Score X: New areas of uptake unlikely to be related to lymphoma. ; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; et al. Barrington, S. F. et al. Blautzik, J.; Grelich, L.; Schramm, N.; Henkel, R.; Bartenstein, P.; Pfluger, T. What and how should we measure in paediatric oncology FDG-PET/CT? PMC Med. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. 2023 Standard of Care. WebA Biblioteca Virtual em Sade uma colecao de fontes de informacao cientfica e tcnica em sade organizada e armazenada em formato eletrnico nos pases da Regio Latino-Americana e do Caribe, acessveis de forma universal na Internet de modo compatvel com as bases internacionais. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Terasawa, T.; Lau, J.; Bardet, S.; Couturier, O.; Hotta, T.; Hutchings, M.; Nihashi, T.; Nagai, H. Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkins lymphoma and diffuse large B-cell lymphoma: A systematic review. You are accessing a machine-readable page. Overall, 26 initial and 49 interim examinations were included. State after first-line standardized chemotherapy was based on the 5-Point Deauville Score. Cumulative burden of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkins lymphoma: An analysis from the St Jude Lifetime Cohort Study. 18F-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is the standard diagnostic test for end-of-treatment assessment in Hodgkin lymphoma1, which accounts for 10% of all diagnosed lymphomas2. Bethesda, MD 20894, Web Policies Imaging 30, 13231341. National Library of Medicine Aleman, B.M.P. Careers. R package version 6.093. FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. doi: 10.1002/14651858.CD007941.pub3. Our study has some limitations. Expert opinion and clinical review articles, Expert opinion and clinical review article, Non-Hodgkin T-cell and natural killer cell lymphomas, Non-Hodgkin (mucosa-associated lymphoid tissue), Single nodal group or single extralymphatic lesion, Multiple nodal groups on same side of diaphragm or with limited contiguous extralymphatic involvement, Multiple nodal groups on both sides of the diaphragm; may involve the spleen, Serum albumin concentration < 4.0 g per dL (40 g per L), Hemoglobin concentration < 10.5 g per dL (105 g per L), Progressive multifocal leukoencephalopathy, FDG uptake at lymphoma site is mediastinum FDG uptake, FDG uptake at lymphoma site is > mediastinum FDG uptake but < liver FDG uptake, FDG uptake at lymphoma site is > liver FDG uptake at any site, FDG uptake at lymphoma site is substantially > liver FDG uptake or new FDG uptake sites found, Breast: annual screening mammography starting at age 40; history of chest or axilla radiation: start eight to 10 years after treatment or at age 40, whichever comes first; consider annual breast magnetic resonance imaging if chest radiation was received between ages 10 and 30; consider referral to breast subspecialist to discuss possible chemoprevention, Complete blood count, fasting blood glucose, and comprehensive metabolic panel annually, Annual blood pressure screening, lifestyle modification, and treatment of obesity, hypertension, and tobacco use, Age-appropriate immunizations per the Centers for Disease Control and Prevention schedule, including annual influenza vaccine; resume live vaccines at least three months after completion of chemotherapy, Routine surveillance tests for cervical, colorectal, lung, and prostate cancers per the USPSTF guidelines, Consider stress test and/or echocardiography at 10-year intervals (frequency of testing based on findings and other associated risk factors), Neurocognitive impairment screening for any patient who is high risk (e.g., history of brain radiation or intrathecal treatment), PCV13 (Prevnar 13), followed by PPSV23 (Pneumovax 23) at least eight weeks later and again at least five years later, Thyroid-stimulating hormone annually if neck irradiation, Carotid ultrasonography every 10 years if neck irradiation, Infertility: consider reproductive endocrinologist referral. Radiomics: The bridge between medical imaging and personalized medicine. Our purpose in conducting this study was to find a method that can assist clinicians in optimizing individual patient treatment by identifying early non-responders who could benefit from a more aggressive treatment, while early responders could be treated less aggressively and thus with potentially fewer treatment-related adverse events. Patient information: See related handout on lymphoma, written by the authors of this article. official website and that any information you provide is encrypted The 5-point scoring system (5p Deauville Score, 5p-DS) has been widely accepted, and it has been proposed as a rapid qualitative method to evaluate interim FDG-PET/CT through visual comparison between the uptake within residual lymphoma tissue to the reference regions mediastinum and liver. Faudemer, J. et al. methods, instructions or products referred to in the content. Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good Ann Oncol 2005;16:1514-23. 2023; 13(3):445. Bull. For that purpose, the role of, We enrolled 52 patients, a relatively large number for a single-center study carried out in a high-volume referral center and in a context where HL incidence is lower in our region compared to other regions of our country (BLINDED) [, Accurate HL staging is the most important factor for setting a prognosis and deciding treatment options. The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. Lancet. Google Scholar. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma(Table 319). However, the prognostic value of residual metabolic tumor volume (rMTV) in patients with DS 4-5 has been less well characterized. Kinahan PE, Fletcher JW. A full list of features with an ICC below 0.8 is given in the supplementary Table S5. Younes A, Santoro A, Shipp M, et al. ; Hudson, M.M. Epub 2017 Sep 5. The site is secure. Oncol. R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). https://doi.org/10.2967/jnumed.116.179648 (2017). Google Scholar. Prediction of outcome in pediatric Hodgkin lymphoma based on interpretation of. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. ; Kostakoglu, L.; Meignan, M.; Hutchings, M.; Meller, S.P. Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the Disclaimer. Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for PET/CT, however, is not always available or may be missing for one or more time points, precluding a reliable prognostic statement based on metabolic activity. ; Diller, L.; DeLaat, C.; Fossati-Bellani, F.; Morgan, E.; Oberlin, O.; et al. PubMed Conceptualization, F.I. Accessibility How to cite this article: John JR, Oommen R, The 2-year progression-free survival (PFS) was 97.3% (95% CI, 91.9 to 99.1) and 92.6% (95% CI, 81.4% to 97.2%) in the BV-AVD and ABVD arms, respectively. Northwestern University, Evanston, Illinois. Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. ; Sherbiny, H.S. PubMed Central Thank you for visiting nature.com. "Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?" Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. Article ; validation, C.F.,H.A. ; formal analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A. The extent and frequency of follow-up specifically depend on the histologic subtype of lymphoma. PubMed Central High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). Le Roux PY, Gastinne T, Le Gouill S, Nowak E, Bodet-Milin C, Querellou S. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri AJ, Vitolo U. Barnes JA, LaCasce AS, Zukotynski K, Israel D, Feng Y, Neuberg D. Sedig LK, Bailey JJ, Wong KK, Brown RK, Kaminski MS, Hutchinson RJ. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). 32, 30593068. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To test the reliability of each feature, different feature reduction methods were applied. Surti, S. et al. Annunziata, S.; Cuccaro, A.; Calcagni, M.L. After two cycles, the primary end point of the study was met: 93 (82.3%; 90% CI, 75.3 to 88.0) of 113 patients in the BV-AVD arm were PET-negative (Deauville score 1 and T.E. Author to whom correspondence should be addressed. Early chemotherapy intensification with escalated BEACOPP in patients with advanced-stage Hodgkin For this reason, it is also important to identify non-responders earlier during the treatment course to optimize the therapeutic strategy. Bertuzzi, C., Sabattini, E. & Agostinelli, C. Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma. Sau Yip Hui et al., Case Rep, 2022. Kwee TC, Kwee RM, Nievelstein RA. Federal government websites often end in .gov or .mil. On scanner B, only flatness and median were selected by all methods. Berenguer, R. et al. Rev. ; Krasin, M.J.; Ness, K.K. Radiology 288, 407415. 21 features overlapped. ; Elsafy, U.R. Shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing rater reliability. MDPI and/or We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. Akhtar S, Rauf SM, Elhassan TA, Maghfoor I. Ann Hematol. Shammas, A.; Lim, R.; Charron, M. Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. Slider with three articles shown per slide. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. Lancet. Results: For 202 patients treated with chemotherapy with or without radiation therapy, the 5-year FFP was 89% (95% confidence interval 85%-93%). ; writingreview and editing, S.N.N., J.M.M.R., D.K., B.H., I.G.S. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Milgrom, S. A. et al. This articledid not receive any funding. Web Close. Julie Faudemer, Nicolas Aide, Charline Lasnon, Queralt Martn-Saladich, Gabriel Reyns-Llompart, Montse Corts-Romera, Sarah A. Milgrom, Hesham Elhalawani, Grace L. Smith, Jeong Rye Kim, Hee Mang Yoon, Jin Seong Lee, Maria E. S. Takahashi, Camila Mosci, Celso D. Ramos, Amandine Cromb, Michle Kind, Olivier Saut, Lea Azour, Jane P. Ko, William H. Moore. The resulting areas under the curve (AUCs) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30. Sci. Article The physician should focus on shared decision-making when discussing treatment options with all patients, but particularly for those older than 60 years, including whether the patient should pursue treatment.25, The standard treatment for Hodgkin lymphoma is ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine [Velban], and dacarbazine), but other regimens such as the Stanford V (doxorubicin, vinblastine, mechlorethamine, etoposide [Toposar], vincristine, bleomycin, and prednisone) and escalated-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine [Matulane], and prednisone) can be used.2428 Treatment for non-Hodgkin lymphoma varies depending on the histology, but often uses treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (Rituxan; R-CHOP), a monoclonal antibody specific for CD20-positive B lymphocytes.29 Other medications such as bendamustine (Bendeka), an alkylating agent, and lenalidomide (Revlimid) are also used in many non-Hodgkin lymphoma treatments.30,31 Common complications of these therapies are listed in Table 5.2527,2936. False-positive patients showed evidence of disease at interim PET-CT imaging but remained in remission during follow-up. https://doi.org/10.1016/j.mri.2012.05.001 (2012). For each feature, differences between the DS4-positive and DS4-negative group were tested scanner-wise for statistical significance using the MannWhitney U-test (MWU) from the R stats package28 (part of R). J. Nucl. Or Milgrom et al., who estimated the relapse rate of mediastinal Hodgkin Lymphoma by building a model with the five most predictive radiomic features from baseline PET scans, yielding promising AUCs13. In another study, Knogler et al. Epub 2022 Jul 25. You seem to have javascript disabled. Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. permission provided that the original article is clearly cited. Song, G. Y. et al. The authors declare no competing interests. Barrington, S.F. https://doi.org/10.1007/s00330-016-4470-8 (2017). Zhao, B. et al. The World Health Organizations classification system identifies more than 90 different subtypes (Table 1).1,2 The initial stratification is derived from B-cell, T-cell, or natural killer cell origin. suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. Lancet Oncol. Between March 2015 and October 2016, 170 patients were enrolled. ; Unal, S.N. A slight misalignment is also visible in (b), which we corrected when we copied the segmentation mask from the CT to the PET images. Nat. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. 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